Later studies revealed the presence of infection in other regions of Africa as well as Asian countries ( 4). Serological studies performed on human serum samples in Uganda later showed the presence of neutralizing antibodies against the virus, providing the first evidence that the virus can infect humans ( 3). Zika virus was first isolated in 1947 in the Zika forest in Uganda from a rhesus macaque ( 2). In recent years, Zika virus infections have attracted the attention of international medical community, chiefly because of their role in causing microcephaly and other neurodevelopmental abnormalities which occur as a consequence of maternal infections ( 1). The major route of transmission for most Flaviviruses is through arthropod vectors and central nervous system injury and hemorrhagic fevers represent major clinical outcomes. Flaviviruses are responsible for several important human diseases including Dengue, West Nile and Yellow fevers, Japanese encephalitis, Tick-borne encephalitis, and Zika fever.
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